Advances in Palladium-Catalyzed Cascade Cyclizations
نویسندگان
چکیده
منابع مشابه
A study of palladium catalyzed intra/intermolecular cascade cross coupling/cyclizations involving bicyclopropylidene.
The compounds [3-(2-Bromocyclohex-2-enyloxy)prop-1-ynyl]-tert-butyl-dimethylsilane 3, [4-(2-bromocyclohex-2-en-1-yloxy)but-2-yn-1-yloxy]tert-butyldimethylsilane 5 and dimethyl 2-(2-bromocyclohex-2-enyl)-2-(3-(tert-butyldimethylsilanyl)prop-2-ynyl)malonate 9 were prepared and subjected to palladium-catalyzed intra-intermolecular cascade cross couplings incorporating bicyclopropylidene 10 under t...
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Catalytic asymmetric oxidation-chemistry involving heteroatom transfer from a reagent to a substrate is perhaps unparalleled in synthetic utility for the construction of enantioenriched materials.[1] Conversely, there is a significant deficiency of asymmetric two-electron oxidations that do not involve heteroatom transfer. Some potentially valuable reactions of this type include the oxidation o...
متن کاملIodoarene-catalyzed cyclizations of unsaturated amides.
The cyclization of N-alkenylamides catalyzed by iodoarenes under oxidative conditions is presented. Five-, six-, and seven-membered rings with a range of substitutions can be prepared by this route. Preliminary data from the use of chiral iodoarenes as precatalysts show that enantiocontrol is feasible.
متن کاملNi(II)-catalyzed enantioselective Nazarov cyclizations.
Nazarov cyclizations are catalyzed by a dicationic Ni(II) complex containing the chiral tridentate phosphine Pigiphos; the catalyst exerts a high degree of torquoselectivity and affords the products in up to 88% ee.
متن کاملDecarboxylative Cyclizations and Cycloadditions of Palladium-polarized Aza-ortho-Xylylenes.
Previously we have shown that palladium catalysts effect the decarboxylation of vinyl oxazinones to form zwitterionic π-allyl palladium intermediates (A, Scheme 1).1 Thus, vinyl oxazinones can be equated with zwitterionic synthons (B). In the absence of other electrophiles, the zwitterionic intermediate cyclizes to form vinyl azetidines with high diastereoselectivity. Moreover, in the presence ...
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ژورنال
عنوان ژورنال: Advanced Synthesis & Catalysis
سال: 2018
ISSN: 1615-4150
DOI: 10.1002/adsc.201800526